![]() In general, however, this ideal cannot be achieved directly from subgroup-specific analyses of clinical trial results because apparent differences between the proportional risk reductions in different subgroups of the patients in a trial (or even in a meta-analysis of many trials) are often surprisingly unreliable. Ideally, therefore, what is wanted from trials is not only an answer to the question ‘Is this treatment helpful on average for a wide range of patients?’, but also an answer to the question ‘For which recognisable categories of patient is this treatment particularly helpful?’ ( EBCTCG, 2005a, 2005b) ![]() For breast cancer, as for many other diseases, treatment that is appropriate for one patient may be inappropriate for another.
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